This article describes the historical development of Armenian translations of Syriac literature from the 5th century, Intermediate and Clinician Periods. Much of the works in the 5th century are attributed to Ephrem the Syrian, containing commentaries, prayers, and hymns. During the Intermediate Period, translations from Syriac slowed, but significant works include letters around the time of the Council of Chalcedon. The Clinician Period is one of renewed interest, especially for commentary, accounts of saints, and other historical works. Mathews refers to the latter period as the “Golden Age” of Syriac-Armenian translation. An appendix lists prominent works in each of the three periods.